September 4 ~ 8, 2016
in Jeju, Korea
Downloads Area

Keynote Speakers

Dieter Söll

Yale University, USA


The Versatility of the genetic code

Peter Dedon

Massachusetts Institute of Technology (MIT), USA


A systems-level perspective on tRNAs, modified ribonucleosides and synonymous codons


Cell Biology and Modification of tRNA I

Eric Phizicky

University of Rochester, USA


tRNA decay pathways in yeast

Sebastian A. Leidel

Max Planck Institute for Molecular Biomedicine, Germany


tRNA decay pathways in yeaThe impact of wobble uridine modifications on translation and protein quality control

Eugene G. Mueller

University of Louisville, USA


Elucidation of the catalytic disulfide and acid base residues in 4-thiouridine synthetase

Ute Kothe

University of Lethbridge, Canada


The tRNA pseudouridine synthase TruB is a tRNA chaperone

Jungwook Kim

GIST, Korea


O-alkylation of wobble uridines in bacterial tRNA


Cell Biology and Modification of tRNA II

Juan Alfonzo

The Ohio State University, USA


Intracellular distribution of maturation factors dictates a dynamic interplay between tRNA splicing and modification in T. brucei.

Kozo Tomita

The University of Tokyo, Japan


Methylation of 5′-phosphate of cytoplasmic tRNAHis in human

Philippe Giegé



On the evolution of RNase P in eukarya

Markus T. Bohnsack

Göettingen University, Germany


NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation

Ru-Juan Liu

Shanghai Institutes for Biological Sciences, China


RNA recognition specificity of the human tRNA m5C methyltransferase NSun6

Seisuke Yamashita

The University of Tokyo, Japan


Mechanism of 3′-matured tRNA discrimination from 3′-immature tRNA by class-II CCA-adding enzyme

Cédric Schelcher



Characterization of protein-only RNase P in complex with tRNA


Cell Biology and Modification of tRNA III

Roland K. Hartmann

Philipps-Universität Marburg, Germany


Aquifex aeolicus RNase P – a cold case finally solved

Dirk Iwata-Reuyl

Portland State University, USA


Role of Archaeosine modification in Archaeal tRNA

Wei Xie

The Sun Yat-Sen University, China


Co-crystal structures provide mechanistic insight into the bifunctional tRNA methyltransferase Trm5a

Wim Versees

Vrije Universiteit Brussel, Belgium


Structural and functional insights into tRNA binding and nucleoside N1-methylation by the tRNA methyltransferase Trm10

Nayef Jarrous

The Hebrew University, Israel


Novel tRNA processing activities in initiation complexes of RNA polymerase III


tRNAomics and systems Biology

Akio Kanai

Keio University, Japan


tRNA gene diversity in Archaea and expansion of non-canonical V-arm-containing tRNAs in Eukaryotes

Todd M. Lowe



Epigenomic analysis of the complete human tRNA gene set reveals an unprecedented view of regulatory complexity

Lluís Ribas de Pouplana

IRB Barcelona, Spain


On the functional limits imposed upon the genetic code by tRNA

Eric Westhof

CNRS-Strasbourg University, France


An integrated, structure- and energy-based view of the genetic code


Non-canonical function of tRNA

Yohei Kirino

Thomas Jefferson University, USA


Repertoire, biogenesis, and function of tRNA halves in hormone-dependent cancers

Norbert Polacek

University of Bern, Sweden


The role of tRNA-derived fragments in stress response

Hong Gil Nam

DGIST, Korea


tRNA-derived fragments control aging in plants and animals

Pavel Ivanov

Harvard Medical School, USA


Diverse biology of tRNA-derived fragments

Susan Martinis

University of Illinois, USA


tRNA variable loop mimetic promotes leucyl-tRNA synthetase dependent RNA annealing to facilitate intron excision of critical
respiratory genes

Laurence Maréchal-Drouard

CNRS, France


RNS and tRFs, two major actors of plant development and stress response

Qi Chen

University of Nevada School of Medicine, USA


Sperm tRNA-derived small RNAs and RNA modifications in diet-induced epigenetic inheritance


Translational Regulation I

Ya-Ming Hou

Thomas Jefferson University, USA


tRNA methylation regulates gene expression

Yaser Hashem

IBMC-ARN CNRS / Université de Strasbourg, France


Structural investigation of the protein translation initiation process in pathogenic protozoa

Kozo Nagano

Nagano Research Institute of Molecular Biology, Japan


Conformational change of tRNA anticodonloop

Ying Huang

Nanjing Normal University, China


The Schizosaccharomyces pombe PPR protein Ppr10 associates with a novel protein Mpa1 and acts as a mitochondrial
translational activator

Alvaro Glavic

University of Chile, Chile


The levels of t6A modification modulate translation, TOR kinase activity and regulates growth

Damien Hermand

The University of Namur, Belgium


Feedback controls between TORC1/2 signaling and tRNA modifications by Elongator regulates nutrient dependent commitment to mitosi


Translational Regulation II

Tsutomu Suzuki

The university of Tokyo, Japan


Insights into molecular pathogenesis of mitochondrial diseases caused by tRNA modification deficiency

Baik L. Seong

Yonsei University, Korea


M1 RNA provides chaperoning function for the folding of C5 protein of RNase P complex for the maturation of tRNAs

Namit Ranjan

Max Max Planck Institute for Biophysical Chemistry, Germany


Loss of thiolation at the tRNA anticodon slows down protein synthesis by impeding decoding and translocation

Francesca Tuorto

German Cancer Research Center (DKFZ), Germany


Influence of Queuosine and 5-methylcytosine tRNA modifications on protein translation in mammals

Stéphanie Lalande

Institut de biologie moléculaire des plantes, CNRS, France


Translation inhibition by tRNA-derived RNA fragments in plants

Hak Kyun Kim

Stanford University, USA


A 3’ tRNA derived small RNA regulates ribosome biogenesis and cell viability


Special Talk

Achim Breiling

EMBO Reports


Transparent Publishing &Open Science: how to share reproducible data


tRNA, tRNA Synthetase and Diseases

Babak Javid

Tsinghua University School of Medicine, China


The mycobacterial indirect tRNA aminoacylation pathway is critical for antibiotic tolerance

Hovav Nechushtan

Hadassah Hebrew University Medical Center, Israel


Lysyl tRNA synthetase phosphorylation by EGFR and lung cancer

Min-Xin Guan

Zhejiang University School of Medicine, China


Mitochondrial tRNA mutations associated with deafness

Yi Shi

The Scripps Research Institute, USA


Hypoxia-induced angiogenesis is controlled by ATM/ATR-SerRS pathway

Kyunggon Kim

University of Ulsan, Korea


Proteomics analysis of thyroid tissues revealed the change of aminoacyl tRNA synthetases and its interacting proteins in follicular thyroid carcinoma and follicular adenocarcinoma

Marie Sissler

CNRS, France


The multiple localizations of the human mitochondrial aspartyl-tRNA synthetase and impact of disease associated mutations

Adrian Gabriel Torres

IRB Barcelona, Spain


Role of ‘wobble’ inosine in gene translation and disease


tRNA Synthetase Biology I

Michael Ibba

The Ohio State University, USA


Translation quality control signals coordination of multiple stress responses in Saccharomyces cerevisiae

Xiang-Lei Yang

The Scripps Research Institute, USA


Evolutionary gain of alanine mischarging to non-cognate tRNAs with a G4:U69 base pair

Hubert D. Becker

University of Strasbourg, France


Existence of two essential and functionally distinct nuclear methionyl-tRNA synthetases in Saccharomyces cerevisiae

Beom Sik Kang

Kyungpook National University, Korea


The crystal structure of human cytosolic methionyl-tRNA synthetase reveals a novel N-terminal linker between its GST and catalytic domains

Rajan Sankaranarayanan

Centre for Cellular and Molecular Biology, India


Mechanistic basis of chiral proofreading and its functional implications


tRNA Synthetase Biology II

Christopher S. Francklyn

University of Vermont, USA


The paradox of histidyl-tRNA synthetase (HARS): a model of tRNA recognition in which two distinct human diseases arise from mutant versions of the same enzyme

Myung Hee Kim

KRIBB, Korea


Immunoregulatory role of multi-tRNA synthetase complex against virus infection

Paul L. Fox

Cleveland Clinic, USA


Origin of the fused aminoacyl tRNA synthetase, glutamyl-prolyl tRNA synthetase

Ignacio Luque

CSIC and Universidad de Sevilla, Spain


Evidence for interaction of membrane-anchored ValRS with FoF1-ATP synthase in a prokaryote

Youngzee Song

The Scripps Research Institute, USA


Functional and structural investigations of a human AlaRS splice variant

Rajat Banerjee

University of Calcutta, India


Promoter DNA binding induces E. coli alanyl-tRNA synthetase (alaRS) oligomerization: Insight into its transcriptional regulation

Kook Son

University of Illinois, USA


A non-canonical function of Leucyl tRNA synthetase in skeletal myogenesis


Genetic Code Reprogramming and Synthetic Biology I

Shigeyuki Yokoyama

RIKEN, Japan


Expansion of the mammalian and bacterial genetic codes and their a9pplication in vivo and in vitro

Jason W. Chin




Wenshe R. Liu

Texas A&M University, USA


The synthesis of structurally defined nucleosomes and its applications

Taek Jin Kang

Dongguk University, Korea


Degeneracy reprogramming for cell-free unnatural amino acid mutagenesis

Patrick O’Donoghue

The University of Western Ontario, Canada


Genetically encoded protein phosphorylation


Genetic Code Reprogramming and Synthetic Biology II

David A. Tirrell

Caltech, USA


Non-canonical amino acids in protein engineering and analysis

Lei Wang



Genetically encoding bioreactivity

Hee-Sung Park

KAIST, Korea


Designer proteins with selective chemical modifications

Min Yao

Hokkaido University, Japan


Template-dependent nucleotide addition in the reverse (3′–5′) direction by TLP

Tae Hyeon Yoo

Ajou University, Korea


Incorporation of noncanonical amino acids in response to the rare AGG codon

Takashi Ohtsuki

Okayama University, Japan


Phototriggered protein syntheses using DEACM-caged aminoacyl tRNAs

Rumit Maini

University of Tokyo, Japan


Ribosome-mediated site-specific incorporation of dipeptides and dipeptidomimetics into proteins


Innovative Technology

Hiroaki Suga

The University of Tokyo, Japan


A RaPID way to discover nonstandard macrocyclic peptides

Hyeyoon Park

Seoul National University, Korea


Watching single endogenous mRNA in neurons in vivo

Pyoung Oh Yoon

Bioneer Corporation, Korea


Idiopathic pulmonary fibrosis (IPF) drug development using SAMiRNA™, a second-generation RNAi Platform

Ahyun Son

Yonsei University, Korea


RNA interaction mediated protein folding vehicle: Virus-like particle (VLP) as recombinant vaccines against viral infection

Satoshi Ishida

The University of Tokyo, Japan


Ribozymes with tRNA recognition and aminoacylation properties

Hye Yeong Nam

Samyang Biopharmaceutical Company, Korea


Long circulating polymeric nanoparticles for efficient siRNA delivery in cancer therapy

Yuichi Miyoshi

Okayama University, Japan


Molecular beacons for detecting tRNAs


Therapeutic Applications of Translational Machinery

Daniel N. Wilson

University of Munich, Germany


Ribosome-targeting antibiotics and mechanisms of bacterial resistance

Jung Min Han

Yonsei University, Korea


From Leucyl-tRNA Synthetase to mTORC1 inhibitor: Overcoming mTOR resistance mutations in cancer

Hyunbo Shim

Ewha Womans University, Korea


Development of monoclonal antibodies against AIMP2-DX2 splice variant

Yoon Soo Chang

Yonsei University College of Medicine, Korea


Clinical implication and diagnostic usefulness of MRS and AIMP2-DX2 in NSCLC


Closing Remarks

Paul Schimmel

The Scripps Research Institute, USA


The broad reach of the tRNA world into new biology